Mietus-Snyder M, Baker A L, Neufeld E J, Roberts C, Dermarkarian S, Beiser A S, Newburger J W
Department of Cardiology, Children's Hospital, Boston, MA 02115.
Am J Dis Child. 1993 Apr;147(4):378-81. doi: 10.1001/archpedi.1993.02160280028012.
To determine the impact of nutritional counseling on lipoprotein profiles in dyslipoproteinemic children.
Retrospective case review.
An academic hospital-based pediatric lipid clinic in Boston, Mass.
One hundred four newly referred children with primary dyslipoproteinemia.
Nutritional recommendations were adapted from the National Cholesterol Education Program's step 2 diet. Three-day diet records were used to assess baseline and follow-up diets.
Two thirds of the children continued to have excellent diets or improved their diets after counseling, but low-density lipoprotein cholesterol (LDL-c) values decreased by 15% or more in only 19% of children. The observed change in LDL-c was not significantly associated with nutritional counseling. However, a strong correlation was evident between dietary interventions and concentration of high-density lipoprotein cholesterol (HDL-c) values in serum. Marked fat restriction lowered HDL-c levels, while liberalization of use of fat, with emphasis on monounsaturates, in a subset of children following an excessively fat-restricted diet on presentation, appeared to improve HDL-c levels.
After nutritional counseling, LDL-c levels decreased by 15% or more in only 19% of dyslipoproteinemic children referred for treatment. There were no clear predictors of LDL-c responsiveness, but changes in dietary fat intake appeared to significantly influence HDL-c levels.
