Zachariae R, Bjerring P
Institute of Psychology, University of Aarhus, Denmark.
Allergy. 1993 Jan;48(1):6-11. doi: 10.1111/j.1398-9995.1993.tb02168.x.
Cutaneous reactivity to challenge with dinitrochlorobenzene (DNCB) and diphenylcyclopropenone (DCP) was studied in 16 volunteers following hypnotic suggestions to increase and decrease response during sensitization. The immunoreactivity to DNCB and DCP was modulated by direct suggestions and guided imagery under hypnosis. The volunteers were highly susceptible subjects selected by means of the Harvard Group Scale of Hypnotic Susceptibility, Form A. Measurement of skin reactions to the challenge 1 month after sensitization was performed double blindly. Results showed a significant (P < 0.01) difference in visually scored reactions to DCP and DNCB between the group instructed to increase reaction to DCP and decrease reaction to DNCB and the group given the opposite instructions. A non-significant difference (P = 0.055) in skin thickness measured by ultrasound was found between the two groups. The study supports previous reports of experimental modulation of immunoreactivity and indicates that the specific immunological processes involved in the development of allergic reactions may be susceptible to psychological factors.
在16名志愿者中研究了对二硝基氯苯（DNCB）和二苯基环丙烯酮（DCP）激发的皮肤反应性，这些志愿者在催眠暗示下进行致敏期间增强和减弱反应。在催眠状态下，通过直接暗示和引导性意象调节对DNCB和DCP的免疫反应性。这些志愿者是通过哈佛团体催眠易感性量表A型挑选出的高度易感受试者。致敏1个月后对激发的皮肤反应进行双盲测量。结果显示，在被指示增强对DCP的反应并减弱对DNCB的反应的组与给予相反指示的组之间，对DCP和DNCB的视觉评分反应存在显著差异（P < 0.01）。两组之间通过超声测量的皮肤厚度存在非显著差异（P = 0.055）。该研究支持了先前关于免疫反应性实验调节的报道，并表明过敏反应发展中涉及的特定免疫过程可能易受心理因素影响。
