Zachariae R, Jørgensen M M, Christensen S, Bjerring P
Institute of Psychology, Aarhus University Hospital, Denmark.
Allergy. 1997 Jul;52(7):760-4. doi: 10.1111/j.1398-9995.1997.tb01235.x.
Delayed-type hypersensitivity (DTH) reactions to the experimental allergen diphenylcyclopropenone (DCP) were measured in four groups, which either trained (+) or did not train in relaxation (-) during the sensitization and/or the challenge phase. All groups consisted of high and low hypnotic susceptible subjects. While there were no differences in erythema, the mean induration of the group which trained in relaxation in both the sensitization and the challenge phase (+/+) was significantly greater than that of the group which trained in relaxation in the challenge phase only (-/+). Significant correlations were found between induration and hypnotic susceptibility scores, and between induration and degree of perceived relaxation during challenge. High hypnotic susceptible subjects experienced a higher degree of perceived relaxation and exhibited greater indurative and erythematous DTH reactions to DCP than low hypnotic susceptible subjects in all four experimental conditions. Though the mediating mechanisms remain unclear, our results suggest that relaxation may affect the DTH reaction, and support previous findings of higher psychophysiologic reactivity of high hypnotic susceptible subjects.
在四组中测量了对实验性变应原二苯环丙烯酮（DCP）的迟发型超敏反应（DTH），这四组在致敏和/或激发阶段要么接受了放松训练（+），要么没有接受放松训练（-）。所有组均由高催眠易感性和低催眠易感性受试者组成。虽然红斑方面没有差异，但在致敏和激发阶段都接受放松训练的组（+/+）的平均硬结明显大于仅在激发阶段接受放松训练的组（-/+）。在硬结与催眠易感性评分之间，以及在硬结与激发期间的感知放松程度之间发现了显著相关性。在所有四种实验条件下，高催眠易感性受试者比低催眠易感性受试者经历了更高程度的感知放松，并且对DCP表现出更大的硬结性和红斑性DTH反应。尽管介导机制尚不清楚，但我们的结果表明放松可能会影响DTH反应，并支持先前关于高催眠易感性受试者具有更高心理生理反应性的研究结果。
