Czarniecki C W, Sonnenfeld G
Genentech, Inc., South San Francisco, California.
APMIS. 1993 Jan;101(1):1-17. doi: 10.1111/j.1699-0463.1993.tb00073.x.
Since its initial description as an antiviral, it has become clear that Interferon-gamma (IFN-gamma) has potent immunoregulatory and cell growth regulatory activities. As a result of these additional activities, it is now apparent that IFN-gamma plays a major role in regulation of bacterial infections. IFN-gamma can be both induced by bacteria and bacterial products; endogenous IFN-gamma production has been shown to play a protective role in the natural host response to several bacterial infections; and administration of exogenous IFN-gamma is effective in the prevention and treatment of bacterial infections in numerous animal model systems. Although it is now clear that IFN-gamma plays a role in regulation of bacterial infections, the mechanisms of its anti-bacterial effects in vivo remain to be established due to the pleiotropic nature of IFN-gamma activity.
自最初被描述为一种抗病毒物质以来，很明显γ干扰素（IFN-γ）具有强大的免疫调节和细胞生长调节活性。由于这些额外的活性，现在很明显IFN-γ在细菌感染的调节中起主要作用。IFN-γ可由细菌和细菌产物诱导产生；内源性IFN-γ的产生已被证明在天然宿主对几种细菌感染的反应中起保护作用；在众多动物模型系统中，外源性IFN-γ的给药在预防和治疗细菌感染方面是有效的。尽管现在很清楚IFN-γ在细菌感染的调节中起作用，但由于IFN-γ活性的多效性，其体内抗菌作用的机制仍有待确定。
