Zaman A G, Graham E M, Sanders M D
Medical Eye Unit, St Thomas's Hospital, London.
Br J Ophthalmol. 1993 Mar;77(3):184-7. doi: 10.1136/bjo.77.3.184.
Non-Hodgkin's lymphoma may have ocular involvement but optic nerve and chiasmal disease is unusual. Determining the cause of the neuropathy in this group of patients presents major difficulties despite modern neuroimaging and immunocytochemistry. Two patients with NHL are presented; one had an anterior chiasmal syndrome and the other bilateral optic nerve involvement. The first patient was thought to have lymphomatous infiltration and the second a concomitant infection (progressive multifocal leucoencephalopathy). Toxic effects of therapy were considered but finally rejected. The importance of modern neuroimaging and the role of optic nerve biopsy are discussed.
非霍奇金淋巴瘤可能累及眼部,但视神经和视交叉疾病并不常见。尽管有现代神经影像学和免疫细胞化学技术,确定这类患者神经病变的病因仍存在重大困难。本文介绍了两名非霍奇金淋巴瘤患者;一名患有视交叉前综合征,另一名双侧视神经受累。第一名患者被认为有淋巴瘤浸润,第二名患者伴有感染(进行性多灶性白质脑病)。曾考虑治疗的毒性作用,但最终排除了这种可能性。文中讨论了现代神经影像学的重要性以及视神经活检的作用。