Juul A, Behrenscheer A, Tims T, Nielsen B, Halkjaer-Kristensen J, Skakkebaek N E
University Department of Growth and Reproduction GR, Rigshospitalet, University of Copenhagen, Denmark.
Clin Endocrinol (Oxf). 1993 Mar;38(3):237-44. doi: 10.1111/j.1365-2265.1993.tb01001.x.
It has recently been shown that patients with growth hormone deficiency have a reduced sweating capacity. We hypothesize that reduced sweating might affect thermoregulation in growth hormone deficiency patients. In the present study we have examined thermoregulation in growth hormone deficiency patients.
Six adult growth hormone deficiency patients and six matched controls were exposed to a 90-minute heat period (40 degrees C). On a second day the subjects exercised for 30 minutes under standardized conditions.
On both occasions changes in GH secretion, sweating and temperature were registered. Heat storage and evaporation were calculated from these data.
We found that during the moderate heat exposure, evaporation was less (56.7 vs 115.6 W, P = 0.0037) and heat storage greater (60.7 vs 37.0 W, P = 0.025) in growth hormone deficiency patients compared to their matched controls. Two of the six patients reacted with severe clinical symptoms of heat exhaustion, whereas the controls were unaffected. After exercise the patients reached significantly higher core temperatures than their matched controls (38.1 vs 37.8 degrees C, P = 0.0097).
Thus, our findings are indicative of a reduced thermoregulatory function in some patients with GH deficiency.
最近研究表明生长激素缺乏患者的出汗能力降低。我们推测出汗减少可能会影响生长激素缺乏患者的体温调节。在本研究中，我们检测了生长激素缺乏患者的体温调节情况。
6名成年生长激素缺乏患者和6名匹配的对照者接受了90分钟的高温暴露（40摄氏度）。第二天，受试者在标准化条件下运动30分钟。
在这两种情况下，均记录生长激素分泌、出汗和体温的变化。根据这些数据计算热量储存和蒸发情况。
我们发现，与匹配的对照者相比，生长激素缺乏患者在中度高温暴露期间，蒸发量较少（56.7瓦对115.6瓦，P = 0.0037），热量储存较多（60.7瓦对37.0瓦，P = 0.025）。6名患者中有2名出现了中暑的严重临床症状，而对照者未受影响。运动后，患者的核心体温显著高于匹配的对照者（38.1摄氏度对37.8摄氏度，P = 0.0097）。
因此，我们的研究结果表明，一些生长激素缺乏患者的体温调节功能降低。
