Rindisbacher L, Hemphill A, Seebeck T
Institute for General Microbiology, University of Bern, Switzerland.
Mol Biochem Parasitol. 1993 Mar;58(1):83-96. doi: 10.1016/0166-6851(93)90093-d.
The major structural component of the cyto-architecture of Trypanosoma brucei is a microtubular array which envelopes the entire cell body and which is in close contact with the overlying cell membrane. A cytoskeletal protein has been identified which is associated with the microtubules of this array at their posterior ends exclusively. This protein, Gb4, is coded for by a very large gene which consists of numerous, tandemly linked repeat units of 0.6 kb length. Despite the large size of the gene, and also of the corresponding mRNA, the mature Gb4 protein has a size of only 28 kDa. Gb4 is well conserved between different species of African trypanosomes.
布氏锥虫细胞结构的主要组成部分是微管阵列，它包裹着整个细胞体，并与覆盖其上的细胞膜紧密接触。已鉴定出一种细胞骨架蛋白，它仅在该阵列微管的后端与之相关联。这种蛋白质Gb4由一个非常大的基因编码，该基因由许多长度为0.6 kb的串联重复单元组成。尽管该基因以及相应的mRNA都很大，但成熟的Gb4蛋白大小仅为28 kDa。Gb4在不同种类的非洲锥虫之间具有高度保守性。
