Combs C A, Singh N B, Khoury J C
Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, Ohio.
Obstet Gynecol. 1993 Apr;81(4):492-6.
To test the hypothesis that elective induction of labor, compared to spontaneous labor, reduces the cesarean rate in women with a sonographic diagnosis of fetal macrosomia.
Sonography results over a period of 27 months were used to select 262 consecutive patients who met the following inclusion criteria: singleton pregnancy at term, estimated fetal weight (EFW) at the 90th percentile or greater, and delivery at our institution. The subjects were divided into four groups based on obstetric management: spontaneous labor (N = 115), elective induction of labor with macrosomia as the sole indication (N = 44), induction of labor for other maternal or fetal indications (N = 48), and elective cesarean delivery (N = 55). The analysis focused on the first two groups. These were compared regarding cesarean rate, indications for cesarean, and shoulder dystocia rate. Multiple logistic regression was used to control for potential confounders.
With elective induction, the cesarean rate was 57%, significantly higher than the 31% rate with spontaneous labor (P < .01). The induced group also had a significantly higher EFW and birth weight. When logistic regression was used to control for birth weight, parity, and care provider, elective induction was still associated with a higher risk of cesarean delivery than was spontaneous labor (adjusted odds ratio 2.7, 95% confidence interval 1.2-5.9; P < .02). Shoulder dystocia occurred in one of 19 vaginal deliveries with elective induction (5.3%) and in two of 79 with spontaneous labor (2.5%).
Because elective induction of labor increased the cesarean rate and did not prevent shoulder dystocia, we conclude that mothers with macrosomic fetuses can safely be managed expectantly unless there is a medical indication for induction.
检验与自然分娩相比,择期引产可降低超声诊断为巨大胎儿的产妇剖宫产率这一假设。
利用27个月期间的超声检查结果,选取262例连续符合以下纳入标准的患者:足月单胎妊娠、估计胎儿体重(EFW)在第90百分位数或以上,且在本机构分娩。根据产科处理方式将受试者分为四组:自然分娩(N = 115)、以巨大儿为唯一指征的择期引产(N = 44)、因其他母体或胎儿指征引产(N = 48)以及择期剖宫产(N = 55)。分析集中在前两组。比较两组的剖宫产率、剖宫产指征及肩难产率。采用多因素逻辑回归分析控制潜在混杂因素。
择期引产组的剖宫产率为57%,显著高于自然分娩组的31%(P <.01)。引产组的EFW和出生体重也显著更高。当采用逻辑回归分析控制出生体重、产次和医护人员时,与自然分娩相比,择期引产仍与更高的剖宫产风险相关(调整优势比2.7,95%置信区间1.2 - 5.9;P <.02)。19例择期引产的阴道分娩中有1例发生肩难产(5.3%),79例自然分娩中有2例发生肩难产(2.5%)。
由于择期引产增加了剖宫产率且未能预防肩难产,我们得出结论,除非有引产的医学指征,巨大胎儿的母亲可安全地期待治疗。