Catalano P M, Roman N M, Tyzbir E D, Merritt A O, Driscoll P, Amini S B
Department of Reproductive Biology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio.
Obstet Gynecol. 1993 Apr;81(4):523-8.
To evaluate weight gain during pregnancy in women with gestational diabetes, and to determine whether there was a stronger or weaker correlation of maternal weight gain with neonatal birth weight in women with gestational diabetes as compared with a control group.
At delivery, 78 women with gestational diabetes and 312 control subjects were evaluated and classified according to pregravid weight for height (underweight, average weight, and overweight). Weight gain during pregnancy and neonatal birth weight in the women with gestational diabetes and in the control group were compared using analysis of covariance, controlling for selected covariables. A weight gain curve for each patient was generated to assess the rate of weight gain during early, middle, and late gestation. Linear regression analysis was used to correlate maternal weight gain and birth weight.
Weight gain was 2.5 kg less in the women with gestational diabetes as compared with the controls (P = .0006). When adjusted for pregravid weight, maternal age, and gestational age at delivery, only underweight women with gestational diabetes persisted in having significantly less weight gain as compared with the control subjects (P = .035). There were no significant differences in infant birth weight between any gestational diabetes and control weight categories. The rate of weight gain was decreased in over-weight women with gestational diabetes versus control subjects in late pregnancy (P = .05). There was a significant correlation between maternal weight gain and birth weight in underweight (r = 0.46, P = .0001) and average-weight (r = 0.17, P = .02) control women but not in overweight controls or in any patients with gestational diabetes.
Weight gain in women with gestational diabetes is less than in control patients, primarily because of greater pregravid weight, and does not correlate with neonatal birth weight.
评估妊娠期糖尿病女性孕期体重增加情况，并确定与对照组相比，妊娠期糖尿病女性孕期体重增加与新生儿出生体重之间的相关性是更强还是更弱。
分娩时，对78例妊娠期糖尿病女性和312例对照者进行评估，并根据孕前身高体重（体重过轻、平均体重和超重）进行分类。采用协方差分析比较妊娠期糖尿病女性和对照组孕期体重增加及新生儿出生体重，并对选定的协变量进行控制。为每位患者生成体重增加曲线，以评估妊娠早期、中期和晚期的体重增加速率。采用线性回归分析来关联孕妇体重增加与出生体重。
与对照组相比，妊娠期糖尿病女性体重增加少2.5kg（P = 0.0006）。在根据孕前体重、产妇年龄和分娩时孕周进行调整后，只有体重过轻的妊娠期糖尿病女性与对照者相比体重增加仍显著较少（P = 0.035）。在任何妊娠期糖尿病和对照体重类别之间，婴儿出生体重均无显著差异。与对照组相比，妊娠期糖尿病超重女性在妊娠晚期体重增加速率降低（P = 0.05）。体重过轻（r = 0.46，P = 0.0001）和平均体重（r = 0.17，P = 0.02）的对照女性中，孕妇体重增加与出生体重之间存在显著相关性，但超重对照女性或任何妊娠期糖尿病患者中则不存在。
妊娠期糖尿病女性的体重增加少于对照患者，主要是因为孕前体重较高，且与新生儿出生体重无关。
