Geber W F, Lefkowitz S S, Hung C Y
J Toxicol Environ Health. 1977 Jan;2(3):577-82. doi: 10.1080/15287397709529458.
The increase in mouse serum interferon that occurs in response to poly I:C administration is markedly attenuated by injection of a narcotic preceding the polynucleotide challenge. A single injection of morphine is capable of inhibiting the mechanism(s) responsible for increasing serum interferon levels for a period of at least 9 days following the narcotic injection. Daily single injections of morphine for 5 or 10 days prior to poly I:C challenge do not amplify the extent of the decrease in serum interferon over that measured for a single injection, even though the amount of narcotic injected is increased on each successive day of the 5 or 10 day period. The implications of this relationship for the phenomenon of narcotic tolerance are evaluated and discussed as they relate to the immune processes.
在多聚肌苷酸-聚胞苷酸（poly I:C）给药后出现的小鼠血清干扰素增加，在多核苷酸激发前注射麻醉剂会使其显著减弱。单次注射吗啡能够在麻醉剂注射后的至少9天内抑制负责提高血清干扰素水平的机制。在poly I:C激发前5天或10天每日单次注射吗啡，与单次注射相比，血清干扰素降低的程度并不会扩大，尽管在这5天或10天期间每天注射的麻醉剂剂量都在增加。这种关系对于麻醉耐受性现象的影响在与免疫过程相关的方面进行了评估和讨论。
