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[抗心律失常活性脒腙取代二苯甲酮。5. (Z)-2-氨基-5-氯二苯甲酮脒腙乙酸盐在溶液中的稳定性]

[Antiarrhythmia active amidinohydrazone substituted benzophenones. 5. The stability of (Z)-2-amino-5-chlorobenzophenone amidinohydrazone acetate in solution].

作者信息

Schleuder M, Richter P H, Keckeis A, Jira T

机构信息

Fachbereich Pharmazie, Ernst-Moritz-Arndt-Universität Greifswald.

出版信息

Pharmazie. 1993 Jan;48(1):33-7.

PMID:8460174
Abstract

The aqueous solution of the title compound can be used for injection for one year if it is stored at room temperature and under light protection. Under these conditions 8% of the E-isomer are produced. The reaction is reversible at day light. Red coloured products of decomposition are formed by long lasting influence of light. At higher temperatures or at sterilisation several products of decomposition are formed which structure is elucidated. For these decomposition a scheme is proposed.

摘要

如果标题化合物的水溶液在室温下避光保存,可用于注射一年。在这些条件下会产生8%的E-异构体。该反应在日光下是可逆的。长时间光照会形成红色分解产物。在较高温度或灭菌时会形成几种分解产物,其结构已被阐明。针对这些分解提出了一个方案。

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