Fujii M, Nakamura M
Jpn Heart J. 1977 Jan;18(1):132-7. doi: 10.1536/ihj.18.132.
Thirty-seven normal rats were used to investigate the effect of ATP on Rb86 clearance of the various organs. Blood pressure was decreased by intravenous bolus injection of 10 or 50 mug ATP/Kg body weight (b.w.). In 10 mug ATP/Kg b.w. infusion, Rb86 clearance of the heart, liver, and pancreas was increased by 43, 29, and 27% respectively. In 50 mug ATP/Kg b.w. infusion which reduced the arterial blood pressure strikingly, Rb86 clearance of the liver and pancreas was increased; and that of the kidney was decreased significantly. The present study may suggest that the effective nutritional blood flow of the heart, liver, and pancreas is increased by intravenous infusion of 10 mug ATP/Kg b.w.
37只正常大鼠用于研究ATP对各器官铷86清除率的影响。通过静脉推注10或50微克ATP/千克体重使血压降低。在10微克ATP/千克体重输注时，心脏、肝脏和胰腺的铷86清除率分别增加43%、29%和27%。在50微克ATP/千克体重输注时，动脉血压显著降低，肝脏和胰腺的铷86清除率增加，而肾脏的铷86清除率显著降低。本研究可能提示，静脉输注10微克ATP/千克体重可增加心脏、肝脏和胰腺的有效营养血流量。
