Poehlman E T, Goran M I, Gardner A W, Ades P A, Arciero P J, Katzman-Rooks S M, Montgomery S M, Toth M J, Sutherland P T
Department of Medicine, College of Medicine, University of Vermont, Burlington 05405.
Am J Physiol. 1993 Mar;264(3 Pt 1):E450-5. doi: 10.1152/ajpendo.1993.264.3.E450.
We considered the association of several metabolic and lifestyle variables as modulators of the decline in resting metabolic rate (RMR) and fat-free weight (FFW) in 183 healthy females (18-81 yr). RMR showed a curvilinear decline with age, which was significant in women aged 51-81 yr but not in women aged 18-50 yr. FFW showed a curvilinear decline with age, which was significant (P < 0.01) in women 48-81 yr but not in women 18-47 yr. The decline in RMR was primarily associated with the loss of FFW (r2 = 72%), whereas the decline in FFW was explained primarily by differences in maximal O2 consumption (VO2max), age, leisure time physical activity, and dietary protein intake (total r2 = 46%). We conclude that RMR and FFW showed a curvilinear decline with age which was accelerated beyond the middle-age years. Second, the age-related decline in RMR was primarily associated with the loss of FFW. Third, the loss of FFW was partially related to a decrement in VO2max and nutritional factors. Therapeutic interventions designed to increase VO2max by elevating physical activity may preserve fat-free weight and thus offset the decline of RMR in aging women.
我们研究了183名健康女性（18 - 81岁）中多种代谢和生活方式变量作为静息代谢率（RMR）和去脂体重（FFW）下降调节因素的相关性。RMR随年龄呈曲线下降，这在51 - 81岁的女性中显著，但在18 - 50岁的女性中不显著。FFW随年龄呈曲线下降，这在48 - 81岁的女性中显著（P < 0.01），但在18 - 47岁的女性中不显著。RMR的下降主要与FFW的减少有关（r2 = 72%），而FFW的下降主要由最大摄氧量（VO2max）、年龄、休闲时间身体活动和膳食蛋白质摄入量的差异所解释（总r2 = 46%）。我们得出结论，RMR和FFW随年龄呈曲线下降，中年以后下降加速。其次，RMR与年龄相关的下降主要与FFW的减少有关。第三，FFW的减少部分与VO2max的降低和营养因素有关。通过增加身体活动来提高VO2max的治疗干预措施可能会保留去脂体重，从而抵消老年女性RMR的下降。
