Poehlman E T, Berke E M, Joseph J R, Gardner A W, Katzman-Rooks S M, Goran M I
Department of Medicine, College of Medicine, University of Vermont, Burlington 05405.
Metabolism. 1992 Aug;41(8):915-21. doi: 10.1016/0026-0495(92)90177-c.
It has been suggested that changes in fat-free weight may not fully explain the decline of resting metabolic rate (RMR) that occurs with aging. We therefore examined the hypothesis that a reduction in maximal aerobic capacity (VO2max) may partially explain the lower RMR in older men, after accounting for differences in fat-free weight and fat weight. We also considered differences in energy intake and plasma thyroid hormones as possible modulators of the age-related decline in RMR in men. Three-hundred healthy men (aged 17 to 78 years) were characterized for: (1) RMR (kcal/min) from indirect calorimetry; (2) body composition from underwater weighing; (3) maximal aerobic capacity from a test of VO2max; (4) plasma thyroid hormones (total triiodothyronine [T3], free T3, total thyroxine [T4], and free T4); and (5) estimated energy intake (kcal/d) from a 3-day food diary. A curvilinear decline of RMR with age was found (P less than .01), in which no relationship was found in men less than 40 years of age (r = .10, slope = 0.002 kcal/min/yr), whereas in men older than 40 years, RMR was negatively related to age (r = -.52, slope = -0.008 kcal/min/yr). After statistical control for differences in fat-free weight and fat weight, a negative relationship between age and RMR persisted (partial r = -.30, P less than .01). It was only after control for fat-free weight, fat weight, and VO2max (partial r = -.10, P greater than .05) that no association between age and RMR was noted.(ABSTRACT TRUNCATED AT 250 WORDS)
有人提出，去脂体重的变化可能无法完全解释随着年龄增长静息代谢率（RMR）的下降。因此，我们检验了这样一个假设：在考虑去脂体重和脂肪重量差异后，最大有氧能力（VO2max）的降低可能部分解释老年男性RMR较低的原因。我们还将能量摄入和血浆甲状腺激素的差异视为男性RMR与年龄相关下降的可能调节因素。对300名健康男性（年龄17至78岁）进行了以下特征测定：（1）通过间接测热法测定的RMR（千卡/分钟）；（2）通过水下称重测定的身体成分；（3）通过VO2max测试测定的最大有氧能力；（4）血浆甲状腺激素（总三碘甲状腺原氨酸[T3]、游离T3、总甲状腺素[T4]和游离T4）；以及（5）通过3天食物日记估算的能量摄入（千卡/天）。发现RMR随年龄呈曲线下降（P小于0.01），其中40岁以下男性未发现相关性（r = 0.10，斜率 = 0.002千卡/分钟/年），而40岁以上男性中，RMR与年龄呈负相关（r = -0.52，斜率 = -0.008千卡/分钟/年）。在对去脂体重和脂肪重量差异进行统计控制后，年龄与RMR之间的负相关仍然存在（偏相关r = -0.30，P小于0.01）。只有在控制去脂体重、脂肪重量和VO2max后（偏相关r = -0.10，P大于0.05），才未发现年龄与RMR之间的关联。（摘要截短于250字）
