Pillon B, Deweer B, Agid Y, Dubois B
Neurology and Neuropsychology Service, Hôpital de la Salpêtrière, Paris, France.
Arch Neurol. 1993 Apr;50(4):374-9. doi: 10.1001/archneur.1993.00540040036010.
OBJECTIVE--Comparing the pattern of spared and impaired memory functions in neurodegenerative diseases known to affect different brain structures. DESIGN--Various situations of acquisition (free encoding or controlled encoding) and retrieval (immediate and delayed free and cued recall, recognition) were used. SETTING--Referral center. PATIENTS--Fifteen for each disease (ie, senile dementia of the Alzheimer type [SDAT], Parkinson's and Huntington's), matched for education, severity of dementia, and depression. MAIN OUTCOME MEASURES--Comparison of free and controlled encoding situations, relationships between memory, executive, and linguistic functions test scores. RESULTS--In the free encoding situation: no difference among the three groups, but higher numbers of intrusions and false recognitions in SDAT. In the controlled situation: cued recall and recognition scores significantly higher in Parkinson's disease and Huntington's disease than in SDAT. Memory performances correlated with executive functions test scores in Huntington's disease and Parkinson's disease, but not in SDAT. All results significant at P < .01. CONCLUSIONS--Clear distinction between the true amnesic syndrome of SDAT, compatible with lesions of hippocampus and temporal cortex, and the inefficient planning of memory processes of Huntington's disease and Parkinson's disease, which might result from a striatofrontal dysfunction.
目的——比较已知会影响不同脑结构的神经退行性疾病中记忆功能保留和受损的模式。设计——采用了各种获取（自由编码或受控编码）和检索（即时和延迟自由及线索回忆、识别）情况。地点——转诊中心。患者——每种疾病各15例（即阿尔茨海默型老年性痴呆[SDAT]、帕金森病和亨廷顿病），在教育程度、痴呆严重程度和抑郁方面进行匹配。主要观察指标——自由和受控编码情况的比较、记忆、执行和语言功能测试分数之间的关系。结果——在自由编码情况下：三组之间无差异，但SDAT组的侵入和错误识别数量较多。在受控情况下：帕金森病和亨廷顿病的线索回忆和识别分数显著高于SDAT组。在亨廷顿病和帕金森病中，记忆表现与执行功能测试分数相关，但在SDAT中不相关。所有结果在P <.01时具有显著性。结论——SDAT真正的遗忘综合征与海马体和颞叶皮质病变相符，与亨廷顿病和帕金森病记忆过程规划效率低下明显不同，后者可能由纹状体额叶功能障碍导致。
