Boyd S J, Nour R, Quinn R J, McKay E, Butler S P
Department of Nuclear Medicine, St. George Hospital, Kogarah, Australia.
Eur J Nucl Med. 1993 Mar;20(3):201-6. doi: 10.1007/BF00169999.
Indium-111 oxine labelled leucocyte (111In oxine leucocyte) scintigraphy is the test of choice in detecting occult infection and localising focal inflammation. 111In oxine labelling is technically difficult and expensive and leucocyte labelling with technetium-99m stannous colloid (99mTc Sn colloid) has been considered to be an alternative. Leucocytes from 40 cases referred for investigation of occult infection or localisation of inflammation were simultaneously labelled with 111In oxine and 99mTc Sn colloid with dual isotope acquisition performed at 1, 3 and 24 h. Twenty-four hour 99mTc Sn colloid scans were corrected for 111In downscatter. Each case was independently interpreted by two experienced observers. Twenty-one patients demonstrated positive 111In oxine leucocyte scans. Using 111In oxine leucocyte scans as the gold standard, 99mTc Sn colloid leucocyte scanning had an overall sensitivity of 86% and a specificity of 95%. Clinical follow-up verified that three patients had false negative 99mTc Sn colloid leucocyte scans and one patient had a false positive. Further clinical evaluation of 99mTc Sn colloid labelled leucocytes is required before they can become a reliable replacement for 111In oxine leucocytes.
铟-111 奥克辛标记白细胞（¹¹¹In 奥克辛白细胞）闪烁扫描是检测隐匿性感染和定位局灶性炎症的首选检查方法。¹¹¹In 奥克辛标记技术难度大且成本高，用锝-99m 亚锡胶体（⁹⁹ᵐTc Sn 胶体）标记白细胞被认为是一种替代方法。对 40 例因隐匿性感染或炎症定位而转诊进行检查的患者的白细胞，同时用¹¹¹In 奥克辛和⁹⁹ᵐTc Sn 胶体进行标记，并在 1 小时、3 小时和 24 小时进行双同位素采集。对 24 小时的⁹⁹ᵐTc Sn 胶体扫描进行¹¹¹In 散射校正。每例由两名经验丰富的观察者独立解读。21 例患者¹¹¹In 奥克辛白细胞扫描呈阳性。以¹¹¹In 奥克辛白细胞扫描作为金标准，⁹⁹ᵐTc Sn 胶体白细胞扫描的总体敏感性为 86%，特异性为 95%。临床随访证实，3 例患者⁹⁹ᵐTc Sn 胶体白细胞扫描出现假阴性，1 例患者出现假阳性。在⁹⁹ᵐTc Sn 胶体标记白细胞能够成为¹¹¹In 奥克辛白细胞的可靠替代方法之前，还需要对其进行进一步的临床评估。
