Reynier M O, Marteau C, Vigne J L, Mule A, Crotte C, Gerolami A
Lipids. 1977 Mar;12(3):254-7. doi: 10.1007/BF02533342.
Incorporation of [1(14)-C] acetate into cholesterol by subcellular particles from the liver and the small intestine of rats with a biliary diversion and a duodenal perfusion of sodium taurocholate, taurochenodeoxycholate or taurodehydrocholate, was studied in vitro. In the liver, taurochenodeoxycholate prevented the increase of cholesterol synthesis induced by biliary drainage. Taurocholate had no action on cholesterol synthesis at any time, day or night. Intestinal synthesis of cholesterol was reduced by taurocholate and taurochenodeoxycholate but was not modified by taurodehydrocholate infusion.
在体外研究了经胆管分流并十二指肠灌注牛磺胆酸钠、牛磺鹅去氧胆酸或牛磺脱氢胆酸的大鼠肝脏和小肠亚细胞颗粒将[1(14)-C]乙酸盐掺入胆固醇的情况。在肝脏中，牛磺鹅去氧胆酸可防止胆汁引流诱导的胆固醇合成增加。牛磺胆酸钠在任何时间（白天或晚上）对胆固醇合成均无作用。牛磺胆酸钠和牛磺鹅去氧胆酸可降低肠道胆固醇的合成，但牛磺脱氢胆酸灌注对其无影响。
