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Jpn J Cancer Res. 1993 Feb;84(2):208-13. doi: 10.1111/j.1349-7006.1993.tb02857.x.
2
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2
Chemotherapy targeting regional lymph nodes by gastric submucosal injection of liposomal adriamycin in patients with gastric carcinoma.胃癌患者胃黏膜下注射脂质体阿霉素靶向区域淋巴结的化疗
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本文引用的文献

1
Liposomal protection of adriamycin-induced cardiotoxicity in mice.脂质体对阿霉素诱导的小鼠心脏毒性的保护作用。
Cancer Res. 1980 May;40(5):1532-7.
2
Characterization, toxicity and therapeutic efficacy of adriamycin encapsulated in liposomes.脂质体包裹阿霉素的表征、毒性及治疗效果
Eur J Cancer Clin Oncol. 1982 Feb;18(2):167-76. doi: 10.1016/0277-5379(82)90060-8.
3
Doxorubicin-induced chronic cardiotoxicity and its protection by liposomal administration.阿霉素诱导的慢性心脏毒性及其脂质体给药的保护作用。
Cancer Res. 1982 May;42(5):1817-25.
4
The anthracycline antineoplastic drugs.蒽环类抗肿瘤药物。
N Engl J Med. 1981 Jul 16;305(3):139-53. doi: 10.1056/NEJM198107163050305.
5
Attenuation of dermal toxicity of doxorubicin by liposome encapsulation.脂质体包封减轻阿霉素的皮肤毒性
Cancer Treat Rep. 1983 May;67(5):481-4.
6
Surgical treatment of early gastric cancer.早期胃癌的外科治疗
Jpn J Clin Oncol. 1984 Jun;14(2):283-93.
7
Intrahepatic uptake and processing of intravenously injected small unilamellar phospholipid vesicles in rats.大鼠体内静脉注射的小单层磷脂囊泡的肝内摄取与处理
Biochim Biophys Acta. 1984 Mar 14;770(2):195-202. doi: 10.1016/0005-2736(84)90130-5.
8
Concentration and time-dependent inter-relationships for antitumour drug cytotoxicities against tumour cells in vitro.体外抗肿瘤药物对肿瘤细胞的细胞毒性的浓度和时间依赖性相互关系。
Int J Cancer. 1983 Jul 15;32(1):7-12. doi: 10.1002/ijc.2910320103.
9
Prevention of chronic doxorubicin cardiotoxicity in beagles by liposomal encapsulation.脂质体包封预防比格犬慢性阿霉素心脏毒性
Cancer Res. 1983 Nov;43(11):5427-32.
10
[Determination of adriamycin and its metabolites in biological samples using high performance liquid chromatography. II. Analysis of tissues by extraction method].[高效液相色谱法测定生物样品中的阿霉素及其代谢产物。II. 采用萃取法分析组织]
Yakugaku Zasshi. 1984 Jun;104(6):620-3. doi: 10.1248/yakushi1947.104.6_620.

兔胃黏膜下脂质体注射靶向淋巴结递送阿霉素

Delivery of lymph node-targeted adriamycin by gastric submucosal liposomal injection in rabbits.

作者信息

Akamo Y, Yotsuyanagi T, Mizuno I, Ichino T, Tanimoto N, Kurahashi S, Saito T, Yamamoto T, Yasui T, Itabashi Y

机构信息

First Department of Surgery, Nagoya City University Medical School.

出版信息

Jpn J Cancer Res. 1993 Feb;84(2):208-13. doi: 10.1111/j.1349-7006.1993.tb02857.x.

DOI:10.1111/j.1349-7006.1993.tb02857.x
PMID:8463137
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5919130/
Abstract

We investigated the feasibility of specifically delivering adriamycin (ADR) to the regional lymph nodes via gastric submucosal injection of liposomal adriamycin (Lipo-ADR) in a rabbit model. We determined the tissue distribution of ADR for up to 7 days after the gastric submucosal injection of Lipo-ADR (0.4 mg/kg of ADR potency) and i.v. administration of an equal dose of free adriamycin (F-ADR). The area under the ADR concentration-time curve (AUC) of the regional lymph nodes was 85.4 micrograms.day/g after gastric submucosal injection of Lipo-ADR and 8.44 micrograms.day/g after i.v. administration of F-ADR. The targeting index of the regional lymph nodes, defined as the ratio of the AUC after gastric submucosal injection of Lipo-ADR to the AUC after i.v. administration of F-ADR, was 10.1. Gastric submucosal injection of Lipo-ADR enhanced lymph node-specific delivery of ADR compared with i.v. administration of F-ADR. The targeting index was 0.47 for the heart, 0.25 for the bone marrow, and 0.41 for the spleen, indicating that gastric submucosal injection of Lipo-ADR reduced delivery of ADR to these organs, as compared with i.v. administration of F-ADR. These data demonstrate that gastric submucosal injection of Lipo-ADR is well suited for specific delivery of ADR to the regional lymph nodes, suggesting that this method of administration may be useful in delivering preoperative adjuvant chemotherapy for preventing gastric cancer recurrence.

摘要

我们在兔模型中研究了通过胃黏膜下注射脂质体阿霉素（Lipo-ADR）将阿霉素（ADR）特异性递送至区域淋巴结的可行性。我们测定了胃黏膜下注射Lipo-ADR（阿霉素效价为0.4mg/kg）和静脉注射等量游离阿霉素（F-ADR）后长达7天的阿霉素组织分布情况。胃黏膜下注射Lipo-ADR后区域淋巴结的阿霉素浓度-时间曲线下面积（AUC）为85.4μg·天/g，静脉注射F-ADR后为8.44μg·天/g。区域淋巴结的靶向指数定义为胃黏膜下注射Lipo-ADR后的AUC与静脉注射F-ADR后的AUC之比，为10.1。与静脉注射F-ADR相比，胃黏膜下注射Lipo-ADR增强了阿霉素向淋巴结的特异性递送。心脏的靶向指数为0.47，骨髓为0.25，脾脏为0.41，这表明与静脉注射F-ADR相比，胃黏膜下注射Lipo-ADR减少了阿霉素向这些器官的递送。这些数据表明，胃黏膜下注射Lipo-ADR非常适合将阿霉素特异性递送至区域淋巴结，提示这种给药方法可能有助于术前辅助化疗以预防胃癌复发。