Bassi F, Neri A S, Gheri R G, Cheli D, Serio M
Dipartimento di Fisiopatologia Clinica, Università di Firenze, Italy.
J Endocrinol Invest. 1993 Feb;16(2):133-7. doi: 10.1007/BF03347666.
In order to evaluate the effects of low-dosage, 6-12 months course of oxandrolone treatment in constitutional delay of growth, we compared the growth responses on treatment, the pattern of sexual development and pubertal growth events, up to final stature of 11 prepubertal boys, aged 10.6-14.1 yr, with those of 11 prepubertal, age-matched untreated controls. Treatment caused a significant increase of height velocity, from 4 to 9 cm/yr, and a significant acceleration of bone maturation, without affecting the timing of onset of puberty, the progression of sexual development or the onset of pubertal growth spurt. On the other hand, oxandrolone induced an earlier skeletal growth arrest but did not affect the expected final height. Treated boys showed an adult stature not significantly different from that of control subjects. Our data suggest that 6 months-1 year, low dosage oxandrolone treatment in constitutionally delayed growth has no significant effect on the pattern of pubertal growth, nor on the rate of sexual maturation or on final height.
为了评估低剂量氧雄龙治疗6 - 12个月对体质性生长延迟的影响，我们比较了11名10.6 - 14.1岁青春期前男孩在接受治疗后的生长反应、性发育模式和青春期生长事件模式，直至最终身高，并与11名年龄匹配的未治疗青春期前对照男孩进行了比较。治疗使身高增长速度显著加快，从每年4厘米增至9厘米，骨骼成熟显著加速，但不影响青春期开始时间、性发育进程或青春期生长突增的开始。另一方面，氧雄龙导致骨骼生长提前停止，但不影响预期的最终身高。接受治疗的男孩成年后的身高与对照受试者无显著差异。我们的数据表明，对于体质性生长延迟，6个月至1年的低剂量氧雄龙治疗对青春期生长模式、性成熟速率或最终身高均无显著影响。
