Kubo I, Muroi H, Himejima M
Division of Entomology and Parasitology, College of Natural Resources, University of California, Berkeley 94720.
J Nat Prod. 1993 Feb;56(2):220-6. doi: 10.1021/np50092a006.
Antifungal activity of three nagilactones isolated from the root bark of Podocarpus nagi (Podocarpaceae), alone and in combination with a variety of phenylpropanoids, was investigated against three fungi, Candida albicans, Saccharomyces cerevisiae, and Pityrosporum ovale. Nagilactone E [2], the most abundant norditerpene dilactone, showed moderate to weak activity against these fungi. This activity was dramatically enhanced by several naturally occurring phenylpropanoids such as anethole [5] and isosafrole. For example, anethole enhanced the activity of nagilactone E as much as 128-fold for C. albicans, decreasing the MIC of this nagilactone from 800 to 6.25 micrograms/ml.
从竹柏(罗汉松科)根皮中分离出的三种纳吉尔内酯单独以及与多种苯丙烷类化合物联合使用时,对白色念珠菌、酿酒酵母和卵形糠秕孢子菌这三种真菌的抗真菌活性进行了研究。纳吉尔内酯E [2],含量最丰富的降二萜双内酯,对这些真菌表现出中等至较弱的活性。几种天然存在的苯丙烷类化合物,如茴香脑 [5] 和异黄樟素,可显著增强这种活性。例如,茴香脑使纳吉尔内酯E对白色念珠菌的活性增强了128倍,将该纳吉尔内酯的最低抑菌浓度从800微克/毫升降至6.25微克/毫升。