Batuev A S, Gafurov B G
Department of the Physiology of Higher Nervous Activity, A.A. Ukhtomskii Institute of Physiology, Leningrad.
Neurosci Behav Physiol. 1993 Jan-Feb;23(1):35-41. doi: 10.1007/BF01182636.
The injection of cholinergic substances (carbocholine, carbathin [karbatin], acetylcholine) into the lateral field of the hypothalamus of cats is accompanied by the appearance in the electrohypothalamogram of characteristic hypersynchronized activity and drinking behavior. The swallowing of water temporarily stops the hypersynchronized activity; the injection of adrenaline into the hypothalamus elicits the same effect. The injection of the same cholinergic preparations into the posterior sigmoid gyrus of the cerebral cortex is accompanied by similar, but less pronounced bioelectrical and behavioral effects. The presentation of a closed drink dispenser containing water to the animals against the background of cholinergic activation of the hypothalamus or cortex leads to desynchronization of the bioelectrical activity and suppression of the bursts of hypersynchronized activity. The drinking behavior of cats which appears on the basis of centrally created thirst motivation reflects the activity of a primary dominant focus in the hypothalamus and of a secondary dominant focus in the sensorimotor cortex. These foci are cholinergic in nature. The cessation of the drinking behavior may be related to the activation of adrenergic mechanisms of the same brain structures.
向猫的下丘脑外侧区域注射胆碱能物质（氨甲酰胆碱、卡巴汀[karbatin]、乙酰胆碱）时，下丘脑电图会出现特征性的高度同步化活动，同时伴有饮水行为。吞咽水会暂时停止高度同步化活动；向下丘脑注射肾上腺素也会产生相同效果。向大脑皮层后乙状回注射相同的胆碱能制剂时，会伴随类似但不太明显的生物电和行为效应。在胆碱能激活下丘脑或皮层的背景下，给动物呈现装有水的封闭式饮水机，会导致生物电活动去同步化，并抑制高度同步化活动的爆发。基于中枢产生的口渴动机而出现的猫的饮水行为，反映了下丘脑的初级优势灶和感觉运动皮层的次级优势灶的活动。这些病灶本质上是胆碱能的。饮水行为的停止可能与同一脑结构的肾上腺素能机制的激活有关。
