Gregor P, Reeves R H, Jabs E W, Yang X, Dackowski W, Rochelle J M, Brown R H, Haines J L, O'Hara B F, Uhl G R
Molecular Neurobiology Section, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224.
Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):3053-7. doi: 10.1073/pnas.90.7.3053.
Receptors for the major excitatory neurotransmitter glutamate may play key roles in neurodegeneration. The mouse Glur-5 gene maps to chromosome 16 between App and Sod-1. The homologous human GLUR5 gene maps to the corresponding region of human chromosome 21, which contains the locus for familial amyotrophic lateral sclerosis. This location, and other features, render GLUR5 a possible candidate gene for familial amyotrophic lateral sclerosis. In addition, dosage imbalance of GLUR5 may have a role in the trisomy 21 (Down syndrome). Further characterization of the murine glutamate receptor family includes mapping of Glur-1 to the same region as neurological mutants spasmodic, shaker-2, tipsy, and vibrator on chromosome 11; Glur-2 near spastic on chromosome 3; Glur-6 near waltzer and Jackson circler on chromosome 10; and Glur-7 near clasper on chromosome 4.
