小鼠白细胞介素-3的cDNA分子克隆
Molecular cloning of cDNA for murine interleukin-3.
作者信息
Fung M C, Hapel A J, Ymer S, Cohen D R, Johnson R M, Campbell H D, Young I G
出版信息
Nature. 1984;307(5948):233-7. doi: 10.1038/307233a0.
DOI:10.1038/307233a0
PMID:6420702
Abstract
The cDNA sequence for murine interleukin-3, one of the colony stimulating factors that regulate haematopoiesis, codes for a polypeptide of 166 amino acids including a putative signal peptide. The predicted amino acid sequence indicates that formation of mature interleukin-3 involves proteolytic removal of not only the signal peptide but additional amino-terminal amino acids.
摘要
小鼠白细胞介素-3的cDNA序列，它是调节造血作用的集落刺激因子之一，编码一个含166个氨基酸的多肽，其中包括一个假定的信号肽。预测的氨基酸序列表明，成熟白细胞介素-3的形成不仅涉及信号肽的蛋白水解去除，还涉及额外的氨基末端氨基酸的去除。
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