Simard A, Vobecky J, Vobecky J S, Ghadirian P, Lamothe-Guay M, Falardeau M
Département de médecine, Faculté de médecine, Université de Montréal, Québec, Canada.
Rev Epidemiol Sante Publique. 1993;41(1):84-9.
An epidemiological case-control study of FBD has been conducted to evaluate the differences observed between cases and controls in relation to the presence or absence of clinical findings and risk factors for fibrocystic breast disease (FBD). A total of 334 patients with FBD were identified among 6,232 women aged 40-59 who had participated in the National Breast Screening Study in Montréal while 340 age-matched controls were selected at random from the same cohort. All women were interviewed by a well trained nurse. Controls were significantly heavier and had a higher body mass index (BMI) than cases; however, cases had longer school attendance than controls. The menstrual cycle was shorter in cases and the number of pregnancies was greater in controls. Significant odds ratios were observed for BMI (O.R. = 0.72, 95% CI = 0.51 - 1.02) suggesting that a higher value of BMI had a rather protective effect; a similar pattern was observed in women using oral contraceptives. Since nodularity was strongly associated with FBD, it was excluded from a model of logistic regression; in this instance, longer school attendance (> 12 years), older age at menopause (> 45 years) and breast pain were significantly associated with an increased risk of FBD.
已开展一项关于纤维囊性乳腺病（FBD）的流行病学病例对照研究，以评估病例组与对照组在纤维囊性乳腺病的临床症状及风险因素的有无方面所观察到的差异。在参与蒙特利尔全国乳腺筛查研究的6232名40至59岁女性中，共识别出334例纤维囊性乳腺病患者，同时从同一队列中随机选取340名年龄匹配的对照。所有女性均由一名训练有素的护士进行访谈。对照组的体重显著更重，体重指数（BMI）也高于病例组；然而，病例组的受教育年限比对照组更长。病例组的月经周期更短，对照组的怀孕次数更多。观察到BMI的优势比有统计学意义（优势比 = 0.72，95%置信区间 = 0.51 - 1.02），表明较高的BMI值具有一定的保护作用；使用口服避孕药的女性也观察到类似模式。由于结节性与纤维囊性乳腺病密切相关，因此在逻辑回归模型中将其排除；在这种情况下，受教育年限更长（> 12年）、绝经年龄更大（> 45岁）以及乳房疼痛与纤维囊性乳腺病风险增加显著相关。
