Hsieh C C, Crosson A W, Walker A M, Trapido E J, MacMahon B
J Natl Cancer Inst. 1984 Feb;72(2):285-90.
The relationship between oral contraceptive (OC) use and occurrence of fibrocystic breast disease (FBD) of different histologic classifications was evaluated with data from a cohort study. Biopsy specimens from 232 women with FBD were classified into different atypia categories. In 96 matched pairs of OC users and nonusers, atypia scores were lower in users than in nonusers. Women without breast diseases (500 OC users and 500 nonusers) were sampled from the original cohort to form a two-stage "anamorphic" study with the 232 cases of FBD. The previously shown inverse association between OC use and FBD occurrence was present and increased with increased length of OC use. However, the "protective effect" of OC use did not vary for different histologic classifications of FBD. The findings from both paired and anamorphic analyses of the data are not consistent with the hypothesis that the use of OC is associated with decreased frequency only of FBD with minimal epithelial atypia.
利用一项队列研究的数据，评估了口服避孕药（OC）的使用与不同组织学分类的纤维囊性乳腺病（FBD）发生之间的关系。对232例患有FBD的女性的活检标本进行了不同异型性类别的分类。在96对匹配的OC使用者和非使用者中，使用者的异型性评分低于非使用者。从原始队列中抽取无乳腺疾病的女性（500名OC使用者和500名非使用者），与232例FBD病例组成两阶段的“变形”研究。先前显示的OC使用与FBD发生之间的负相关关系存在，且随着OC使用时间的延长而增强。然而，OC使用的“保护作用”在FBD的不同组织学分类中并无差异。对数据进行配对分析和变形分析的结果均与以下假设不一致：即使用OC仅与上皮异型性最小的FBD发生频率降低有关。
