Partanen T
Institute of Occupational Health, Helsinki, Finland.
Scand J Work Environ Health. 1993 Feb;19(1):8-15. doi: 10.5271/sjweh.1500.
A recent meta-analysis by Blair and his co-workers stimulated the undertaking of a reanalysis of the epidemiologic evidence of an association between formaldehyde and respiratory cancer. Emphasis was placed on extracting the maximal amount of relevant data from the source studies. In close agreement with the original analysis, the aggregated evidence did not indicate an excess risk or an exposure-response gradient for lung cancer. An exposure-response gradient was seen for both sinonasal and nasopharyngeal cancers. The risk for substantial exposure was significantly elevated (odds ratio 1.7 for sinonasal and 2.7 for nasopharyngeal cancer). It is suggested that at least substantial levels of occupational exposure to formaldehyde are associated with a risk of these cancers. The excess risk would be of the order of 100% or more over background rates.
布莱尔及其同事最近进行的一项荟萃分析促使人们重新分析甲醛与呼吸道癌症之间关联的流行病学证据。重点是从原始研究中提取最大量的相关数据。与原始分析结果密切一致，汇总证据并未表明肺癌存在超额风险或暴露-反应梯度。鼻窦癌和鼻咽癌均呈现出暴露-反应梯度。大量暴露的风险显著升高（鼻窦癌的优势比为1.7，鼻咽癌为2.7）。研究表明，至少大量的职业性甲醛暴露与这些癌症的风险相关。超额风险将比背景发病率高出100%或更多。
