Hall A, Nahar Q
International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka.
Trans R Soc Trop Med Hyg. 1993 Jan-Feb;87(1):84-6. doi: 10.1016/0035-9203(93)90435-s.
Albendazole, a broad spectrum anthelmintic recently shown to be active in vitro against Giardia duodenalis, was given at 4 different dosages and compared with metronidazole in the treatment of children in Bangladesh infected with Giardia. Three stools were collected over 10 d after treatment and examined microscopically. Albendazole was found to be effective: single doses of either 600 mg (n = 103) or 800 mg (n = 114) successfully treated 62% and 75% of infections, respectively; 400 mg given either once a day for 3 d (n = 116) or for 5 d (n = 115) successfully treated 81% and 95% of all infections, respectively. Albendazole given daily at 400 mg for 5 d was as effective as metronidazole, which cured 97% of infections (n = 230). Albendazole may thus be an alternative treatment for infections with Giardia, while the moderate efficacy of single doses may provide a benefit in addition to its effects on several species of intestinal helminths.
阿苯达唑是一种广谱驱虫药，最近显示在体外对十二指肠贾第鞭毛虫有活性。在孟加拉国，对感染贾第虫的儿童给予4种不同剂量的阿苯达唑，并与甲硝唑进行治疗比较。治疗后10天内收集3次粪便并进行显微镜检查。结果发现阿苯达唑有效：单次服用600毫克（n = 103）或800毫克（n = 114）分别成功治愈了62%和75%的感染；每天服用400毫克，连续服用3天（n = 116）或5天（n = 115）分别成功治愈了81%和95%的所有感染。每天服用400毫克阿苯达唑，连续服用5天，其效果与甲硝唑相同，甲硝唑治愈了97%的感染（n = 230）。因此，阿苯达唑可能是治疗贾第虫感染的一种替代疗法，而单次剂量的中等疗效除了对几种肠道蠕虫有作用外，可能还有其他益处。
