Nascimento M D, Alcântara-Neves N M, Muniz M E, Nunes S F, Paranhos M, de Carvalho L C
Departamento de Patologia, Universidade Federal do Maranhao, Sao Luis, Brazil.
Trans R Soc Trop Med Hyg. 1993 Jan-Feb;87(1):91-3. doi: 10.1016/0035-9203(93)90439-w.
The intradermal inoculation in naive or in previously sensitized individuals of small amounts of Leishmania extract (Montenegro's skin test) induced or modulated, respectively, the immune response to Leishmania, as assessed by subsequent Montenegro's skin tests. These phenomena could hinder the interpretation of Montenegro's skin tests in a population already subjected to the test in the past and, in addition, could affect in an unknown way the development of mucosal lesions in people infected with L. braziliensis or L. amazonensis, since those lesions have been associated with hypersensitivity to Leishmania antigens. Anti-Leishmania antibody responses, assessed by enzyme-linked immunosorbent assay, were not induced in naive individuals by Montenegro's skin tests, but tended to become more intense following these tests in previously sensitized individuals.
通过后续的蒙氏皮肤试验评估发现，在未致敏个体或先前已致敏个体中皮内接种少量利什曼原虫提取物（蒙氏皮肤试验），分别诱导或调节了对利什曼原虫的免疫反应。这些现象可能会妨碍对过去已接受过该试验人群中蒙氏皮肤试验结果的解读，此外，还可能以未知方式影响感染巴西利什曼原虫或亚马逊利什曼原虫的人黏膜病变的发展，因为这些病变与对利什曼原虫抗原的超敏反应有关。通过酶联免疫吸附测定评估的抗利什曼原虫抗体反应，在未致敏个体中不会因蒙氏皮肤试验而诱导产生，但在先前已致敏个体中，这些试验后抗体反应往往会变得更强烈。
