Ullman S, Halberg P, Høier-Madsen M, Kang L, Konstantinov K, Pedersen K, Rasmussen E, Wiik A
Autoimmunafdelingen, Statens Seruminstitut, København.
Ugeskr Laeger. 1993 Feb 15;155(7):472-6.
In order to evaluate the practical clinical value of centromere, Scl-70, and nucleolar antibodies as demonstrated routinely by the Autoimmune Department of the Serum Institute of Copenhagen, 1293 sera from 497 patients with scleroderma (SSc) and other connective tissue diseases were tested for the three antibodies and for other nuclear antibodies. The three antibodies were found in 32, 15 and 15%, respectively, of sera from patients with SSc. Since more than one of the three antibodies was rarely demonstrated in any one serum, one of them was found in two thirds of sera from patients with SSc. The specificity of the three antibodies for SSc was 95% or more. Centromere antibody was found most frequently in patients with limited SSc. Scl-70 antibody was found almost exclusively in sera from patients with extensive SSc (involving the skin of the trunk). In such sera, centromere antibody was found in only 21%. Scl-70 antibody was overrepresented and centromere antibody was underrepresented in sera from patients with pulmonary involvement, the converse being true for sera from patients with calcinosis, esophageal involvement and telangiectasia.
为了评估由哥本哈根血清研究所自身免疫科常规检测的着丝点抗体、Scl-70抗体和核仁抗体的实际临床价值，对497例硬皮病（SSc）患者和其他结缔组织病患者的1293份血清进行了这三种抗体及其他核抗体的检测。在硬皮病患者的血清中，分别有32%、15%和15%检测到这三种抗体。由于在任何一份血清中很少同时出现这三种抗体中的一种以上，所以在三分之二的硬皮病患者血清中发现了其中一种抗体。这三种抗体对硬皮病的特异性为95%或更高。着丝点抗体在局限性硬皮病患者中最常见。Scl-70抗体几乎仅在弥漫性硬皮病（累及躯干皮肤）患者的血清中发现。在这类血清中，仅21%发现有着丝点抗体。在有肺部受累的患者血清中，Scl-70抗体占比过高，着丝点抗体占比过低，而在有钙质沉着、食管受累和毛细血管扩张的患者血清中情况则相反。
