Ruffatti A, Calligaro A, Ferri C, Bombardieri S, Gambari P F, Todesco S
J Clin Lab Immunol. 1985 Apr;16(4):227-9.
In testing for antinuclear antibodies the sera of 121 patients affected with scleroderma, we found in 2 of them the concurrent presence of anti-centromere and anti-Scl 70 antibodies. Since the association of these antibodies has never been reported, to the best of our knowledge, we report the clinical and serological features of the 2 patients. Both subjects were women with an incomplete CREST syndrome (RST), a relatively limited involvement of the skin, a mild pulmonary fibrosis without apparent signs of other visceral involvement. On the other hand, the clinical course of the disease was different in the 2 cases. One patient had a longer disease duration and up to date the clinical features appear to be unchanged; the other had a shorter disease duration, when suddenly she died of cardiac arrest.
在对121例硬皮病患者的血清进行抗核抗体检测时，我们发现其中2例同时存在抗着丝点抗体和抗Scl 70抗体。据我们所知，这些抗体的关联此前从未有过报道，因此我们报告这2例患者的临床和血清学特征。两名患者均为女性，患有不完全性CREST综合征（RST），皮肤受累相对局限，有轻度肺纤维化，无其他内脏受累的明显迹象。另一方面，这2例患者的疾病临床过程有所不同。一名患者病程较长，至今临床特征似乎未变；另一名患者病程较短，突然死于心脏骤停。
