Otte P
Z Gerontol. 1993 Jan-Feb;26(1):2-7.
The incidence of arthroses has a highly significant correlation with age. However, a clearly defined relationship from a causal basis does not yet exist. This association is not through the time-dependent accumulation derived from the mechanical "destruction-quantum" at a molecular level in the cartilage. Indicative for the transformation is progressive degeneration with considerations of disease values, norms, and biochemical parameters of the joint and associated indicators. We use the example of the knee joint to illustrate this point. The discrepancy over deficit in strength and regulatory mechanisms is also considered, as well as the passive chondroprotective shock-absorption of the subchondralia spongiosa, and, conversely, the apparent protective mechanism of osteoporosis preceding arthrosis. Epidemiologically, osteoporosis and arthroses have been proven incompatible; what remains to be elucidated is the well-known dichotomy in their courses of development.
关节病的发病率与年龄高度相关。然而，尚未存在基于因果关系的明确界定关系。这种关联并非源于软骨分子水平上机械性“破坏量”随时间的积累。考虑到关节的疾病值、规范、生化参数及相关指标，渐进性退变是转变的指征。我们以膝关节为例来说明这一点。还考虑了力量和调节机制方面的不足差异，以及软骨下松质骨的被动软骨保护减震作用，反之，还考虑了关节病之前骨质疏松的明显保护机制。从流行病学角度看，骨质疏松和关节病已被证明是不相容的；有待阐明的是它们发展过程中众所周知的二分法。
