Heise N, Toledo O M
Faculdade de Medicina da Universidade de Sao Paulo, Disciplina de Reumatologia, Brasil.
Ann Anat. 1993 Feb;175(1):35-40. doi: 10.1016/s0940-9602(11)80234-7.
In spite of the fact that the various anatomical regions of a given articular cartilage surface are subjected to different degrees of stress, the present observations strongly suggest that there exists a topographical homogeneity in the distribution of glycosaminoglycans in the same articular cartilage. In contrast to this age-related changes in the proportion of the different types of glycosaminoglycan species in articular cartilage are remarkable. Non-sulphated chondroitin could only be detected in very young articular cartilage. Dermatan sulphate, which has already been detected in young adult rabbits, was followed by the appearance of keratan sulphate in older rabbits. Chondroitin 4-6-sulphates were detected in all articular cartilages studied, the proportion of the 6-sulphated variably increasing with age. The present report suggests that the distribution of glycosaminoglycans in articular cartilage varies with species and age, and the data can further vary, depending on the methods used. It is therefore concluded that generalizations against the results reported in the literature should be considered skeptically.
尽管特定关节软骨表面的各个解剖区域承受着不同程度的应力，但目前的观察结果强烈表明，同一关节软骨中糖胺聚糖的分布存在地形学上的均匀性。与此形成对比的是，关节软骨中不同类型糖胺聚糖种类的比例随年龄变化显著。非硫酸化软骨素仅在非常年轻的关节软骨中被检测到。硫酸皮肤素已在成年幼兔中被检测到，随后在老年兔中出现了硫酸角质素。在所研究的所有关节软骨中均检测到了硫酸软骨素4-6硫酸酯，6-硫酸化的比例随年龄变化而不同程度增加。本报告表明，关节软骨中糖胺聚糖的分布随物种和年龄而异，并且数据可能会因所使用的方法而进一步变化。因此得出结论，对于文献中报道的结果进行一概而论应持怀疑态度。
