Kavsan V, Koval A, Petrenko O, Roberts C T, LeRoith D
Institute of Molecular Biology and Genetics, Ukrainian Academy of Sciences, Kiev.
Biochem Biophys Res Commun. 1993 Mar 31;191(3):1373-8. doi: 10.1006/bbrc.1993.1369.
According to the accepted hypothesis, polyploid evolution is necessary to achieve meaningful gene duplication. Some fish, namely those belonging to the suborder Salmonidae, appear to be autotetraploid species that probably originated from a diploid ancestor relatively recently and that appear to be progressing toward diploidization to various degrees. The Pacific chum salmon (Oncorhynchus keta) has almost completed this process of diploidization. Thus, with regard to practically any gene product, theory predicts a freshly diploidized, autotetraploid species to possess twice the number of gene loci as diploid animals. Here we show that the chum salmon genome contains two nonallelic insulin genes that are both expressed in chum salmon Brockman bodies. Nucleotide sequence analysis reveals structural diversification of this pair of duplicated genes.
根据公认的假说，多倍体进化对于实现有意义的基因复制是必要的。一些鱼类，即鲑科亚目的那些鱼类，似乎是同源四倍体物种，它们可能相对较近地起源于二倍体祖先，并且似乎正朝着不同程度的二倍体化发展。太平洋大麻哈鱼（Oncorhynchus keta）几乎已经完成了这个二倍体化过程。因此，对于几乎任何基因产物，理论预测一个新二倍体化的同源四倍体物种拥有的基因座数量是二倍体动物的两倍。在这里我们表明，大麻哈鱼基因组包含两个非等位胰岛素基因，它们都在大麻哈鱼布罗克曼小体中表达。核苷酸序列分析揭示了这对重复基因的结构多样性。
