Perko V, Falaschi C
Minerva Med. 1977 Feb 18;68(8):515-22.
30 subjects suffering from obstructive type chronic bronchopneumopathies were treated with salbutamol, a new Beta2 stimulating bronchodilator, administered by aerosol in a single dose of 200 gamma. Clinically the bronchospasm resolved itself or was reduced in just a few minutes in more than 70% of cases. Functionally, the various spirometric parameters were followed up for six hours and showed that the drug is capable of reducing flow resistance in rapid, lasting fashion, thus improving airway conductivity and making lung ventilation more homogeneous. No cardiovascular alterations were encountered.