Glöckner R, Schwarz S, Jähne F
Institute of Pharmacology and Toxicology, Friedrich Schiller University Jena, Germany.
Exp Toxicol Pathol. 1993 Feb;45(1):35-7. doi: 10.1016/S0940-2993(11)80449-5.
Female Uje:WIST rats were exposed to lithium (20 mmol LiCl/l drinking water, lithium levels about 1 mmol/l serum) for at least three weeks before mating and continuously up to the end of gestation. Female F1-offspring were raised without further treatment and mated at an age of 90-120 days with untreated males. The effect of chronic restraint stress during gestation on pregnancy outcome was estimated. Moderate changes (higher frequency of prolonged gestation, decreased body mass of the newborn pups) resembled those which were induced by considerably longer stress exposure (extended to the premating period) of prenatally untreated female Uje:WIST rats. An enhanced stress sensitivity following prenatal lithium treatment is discussed.
雌性Uje:WIST大鼠在交配前至少三周暴露于锂（饮用水中含20 mmol LiCl/L，血清锂水平约1 mmol/L），并持续至妊娠结束。雌性F1代后代在不进行进一步处理的情况下饲养，90 - 120日龄时与未处理的雄性交配。评估了妊娠期慢性束缚应激对妊娠结局的影响。适度变化（妊娠延长频率更高，新生幼崽体重减轻）类似于未接受产前处理的雌性Uje:WIST大鼠在相当长的应激暴露（延长至交配前期）后所诱导的变化。讨论了产前锂处理后应激敏感性增强的情况。
