Sale G E, Beauchamp M
Department of Pathology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104.
Bone Marrow Transplant. 1993 Mar;11(3):223-5.
We sought to determine the frequency of parafollicular hair bulge involvement in human GVHD of the skin. The parafollicular bulge was recently shown by Murphy to be a target of GVHD in the minor histoincompatible mouse GVHD model. We sought a crude estimate of this frequency by studying 541 skin biopsy reports from a 5-month period at our bone marrow transplant center. We selected 170 slides for review on the basis of a prior histological diagnosis of GVHD. Of these 41 had potentially evaluable pilar units and were recut. Three cases were considered unevaluable but the remaining 38 cases all showed positive evidence of involvement of the parafollicular hair bulge. The data confirm that the parafollicular hair bulge is involved with very high frequency in acute GVHD in humans.
我们试图确定人皮肤移植物抗宿主病（GVHD）中毛囊旁隆突受累的频率。墨菲最近表明，在次要组织相容性小鼠GVHD模型中，毛囊旁隆突是GVHD的一个靶点。我们通过研究我们骨髓移植中心5个月期间的541份皮肤活检报告，对这一频率进行了粗略估计。我们根据先前的GVHD组织学诊断选择了170张切片进行复查。其中41例有潜在可评估的毛囊单位并重新切片。3例被认为不可评估，但其余38例均显示有毛囊旁隆突受累的阳性证据。数据证实，在人类急性GVHD中，毛囊旁隆突受累频率非常高。
