白三烯在豚鼠气道高反应性中的作用。
Role of leukotrienes in airway hyperresponsiveness in guinea-pigs.
作者信息
Ishida K, Thomson R J, Schellenberg R R
机构信息
UBC Pulmonary Research Laboratory, St. Paul's Hospital, Vancouver, B.C., Canada.
出版信息
Br J Pharmacol. 1993 Mar;108(3):700-4. doi: 10.1111/j.1476-5381.1993.tb12864.x.
Abstract
- Repeated aerosolization of leukotriene C4 (LTC4) to guinea-pigs produced leftward shift in their pulmonary resistance (RL) dose-response curves to inhaled acetylcholine (ACh) without increasing the maximum responses. 2. Repeated LTC4 aerosolization did not increase airway eosinophils. 3. The 5-lipoxygenase-activating protein (FLAP) inhibitor, MK-886, prevented the leftward shift in RL dose-response curves to ACh following repeated antigen challenge in guinea-pigs. 4. MK-886 did not inhibit the increased maximal RL produced by repeated antigen challenge, nor inhibit the airway eosinophilia induced by repeated antigen challenge. 5. Our findings suggest that leukotrienes may account for the leftward shift in pulmonary resistance responses caused by antigen but do not cause the airway eosinophilia nor enhanced maximum broncho-constrictor response to antigen.
摘要
- 对白鼠反复雾化吸入白三烯C4（LTC4），可使其对吸入乙酰胆碱（ACh）的肺阻力（RL）剂量反应曲线向左移位，但最大反应未增加。2. 反复雾化吸入LTC4未增加气道嗜酸性粒细胞。3. 5-脂氧合酶激活蛋白（FLAP）抑制剂MK-886可防止豚鼠反复抗原激发后RL对ACh的剂量反应曲线向左移位。4. MK-886不抑制反复抗原激发所产生的最大RL增加，也不抑制反复抗原激发所诱导的气道嗜酸性粒细胞增多。5. 我们的研究结果表明，白三烯可能是抗原引起肺阻力反应向左移位的原因，但不会引起气道嗜酸性粒细胞增多，也不会增强对抗原的最大支气管收缩反应。
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