Sadovnick A D, Ebers G C
Multiple Sclerosis Clinic, University Hospital-UBC Site, Vancouver, Canada.
Can J Neurol Sci. 1993 Feb;20(1):17-29. doi: 10.1017/s0317167100047351.
The decisive conclusions to be drawn from the available epidemiological data, mostly geography and prevalence, of MS are: (1) a north-south (as well as west-east in the United States) gradient exists independent of genetic/racial factors; (2) major differences in prevalence occur in the absence of latitude differences; (3) individuals from the same ethnic derivation have either similar prevalence rates or very different prevalence rates in widely separated geographical areas and (4) specific resistant isolates are shown to exist regardless of latitude. Existing information leads to the almost inescapable conclusion that the epidemiology of MS cannot be explained by any single known environmental or genetic factor(s) in isolation. A combination of a heterogeneous distribution of both genetic and environmental factors appears to be required to explain the available data on MS.
从现有的关于多发性硬化症（MS）的流行病学数据（主要是地理分布和患病率）中得出的决定性结论如下：（1）存在南北梯度（在美国为东西梯度），且与遗传/种族因素无关；（2）在不存在纬度差异的情况下，患病率存在重大差异；（3）来自同一族裔的个体在相距甚远的地理区域中，患病率要么相似，要么差异很大；（4）无论纬度如何，都存在特定的抗性隔离群。现有信息几乎不可避免地得出这样的结论：MS的流行病学无法用任何单一已知的环境或遗传因素单独解释。似乎需要遗传和环境因素的异质分布相结合来解释关于MS的现有数据。
