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Trisomy 14 in hematologic diseases. Another non-random abnormality within myeloid proliferative disorders.

作者信息

Mancini M, Cedrone M, Nanni M, Rondinelli M B, Petti M C, De Cuia M R, Alimena G

机构信息

Department of Human Biopathology, University La Sapienza, Rome, Italy.

出版信息

Cancer Genet Cytogenet. 1993 Mar;66(1):39-42. doi: 10.1016/0165-4608(93)90146-d.

DOI:10.1016/0165-4608(93)90146-d
PMID:8467473
Abstract

Two cases of myelodysplastic syndrome (MDS) and a case of acute nonlymphoblastic leukemia (ANLL) with a trisomy 14 are presented. The series of results derived from our cases, and those previously reported, strongly suggest that this anomaly may be another nonrandom change, confined within myeloid disorders and associated with patients' advanced age, marked tendency to bone marrow dysplastic features, normal platelet values, and not unfavorable prognosis.

摘要

相似文献

1
Trisomy 14 in hematologic diseases. Another non-random abnormality within myeloid proliferative disorders.
Cancer Genet Cytogenet. 1993 Mar;66(1):39-42. doi: 10.1016/0165-4608(93)90146-d.
2
Is trisomy 11 another nonrandom chromosomal anomaly in acute nonlymphocytic leukemia and myelodysplastic syndromes?11三体是急性非淋巴细胞白血病和骨髓增生异常综合征中另一种非随机染色体异常吗?
Cancer Genet Cytogenet. 1988 Oct 15;35(2):205-11. doi: 10.1016/0165-4608(88)90242-7.
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Trisomy 14: a recurring cytogenetic abnormality associated with myeloid disorders.14号染色体三体:一种与髓系疾病相关的复发性细胞遗传学异常。
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Karyotypic conversion from trisomy 4 to trisomy 14 during the evolution of therapy-related myelodysplastic syndrome to acute myeloblastic leukemia.在治疗相关的骨髓增生异常综合征向急性髓系白血病演变过程中,核型从4三体转变为14三体。
Cancer Genet Cytogenet. 2002 Jan 1;132(1):83-4. doi: 10.1016/s0165-4608(01)00525-8.
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Trisomy 14 is a non-random karyotypic abnormality associated with myeloid malignancies.14号染色体三体是一种与髓系恶性肿瘤相关的非随机核型异常。
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Trisomy 11 in myelodysplastic syndrome-derived acute myeloblastic leukaemias.骨髓增生异常综合征衍生的急性髓系白血病中的11号染色体三体
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Myelodysplastic syndrome and trisomy 14q.骨髓增生异常综合征与14号染色体长臂三体
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Detection of monosomy 7 and trisomies 8 and 11 in myelodysplastic disorders by interphase fluorescent in situ hybridization. Comparison with acute non-lymphocytic leukemias.应用间期荧光原位杂交技术检测骨髓增生异常综合征中的7号染色体单体及8号和11号染色体三体。与急性非淋巴细胞白血病的比较。
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Single nucleotide polymorphism array-based karyotyping in acute myeloid leukemia or myelodysplastic syndrome with trisomy 8 as the sole chromosomal abnormality.基于单核苷酸多态性微阵列的核型分析在伴 8 号染色体三体的急性髓系白血病或骨髓增生异常综合征中的应用。
Acta Haematol. 2013;129(3):154-8. doi: 10.1159/000343420. Epub 2012 Nov 30.

引用本文的文献

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Germline duplication of ATG2B and GSKIP predisposes to familial myeloid malignancies.胚系 ATG2B 和 GSKIP 基因重复导致家族性髓系恶性肿瘤。
Nat Genet. 2015 Oct;47(10):1131-40. doi: 10.1038/ng.3380. Epub 2015 Aug 17.
2
Rare cytogenetic abnormalities in myelodysplastic syndromes.骨髓增生异常综合征中的罕见细胞遗传学异常
Mediterr J Hematol Infect Dis. 2015 May 1;7(1):e2015034. doi: 10.4084/MJHID.2015.034. eCollection 2015.
3
Trisomy 14 as a sole chromosome abnormality is associated with older age, a heterogenous group of myeloid neoplasms with dysplasia, and a wide spectrum of disease progression.
14号染色体三体作为唯一的染色体异常与高龄、一组具有发育异常的异质性髓系肿瘤以及广泛的疾病进展相关。
J Biomed Biotechnol. 2010;2010:365318. doi: 10.1155/2010/365318. Epub 2011 Jan 20.
4
Current status of human chromosome 14.人类14号染色体的现状
J Med Genet. 2002 Feb;39(2):81-90. doi: 10.1136/jmg.39.2.81.