Taillan B, Garnier G, Castanet J, Ferrari E, Pesce A, Dujardin P
Service de Médecine Interne, Hôpital de Cimiez, Nice, France.
Clin Rheumatol. 1993 Mar;12(1):93-4. doi: 10.1007/BF02231567.
We report one case of non-Hodgkin lymphoma in a patient, with a 30-year history of rheumatoid arthritis, taking low dose methotrexate weekly over a 10-month period. The mild immunosuppression that occurs with methotrexate therapy probably places patients with rheumatoid arthritis at added risk of developing lymphoproliferative diseases, but coincidence cannot be excluded.
我们报告了一例非霍奇金淋巴瘤患者，该患者有30年类风湿关节炎病史，在10个月期间每周服用低剂量甲氨蝶呤。甲氨蝶呤治疗引起的轻度免疫抑制可能使类风湿关节炎患者发生淋巴增殖性疾病的风险增加，但也不能排除巧合因素。
