Lin H C, Tyler J W, Wallace S S, Thurmon J C, Wolfe D F
Department of Large Animal Surgery and Medicine, College of Veterinary Medicine, Auburn University, Alabama 36849-5522.
Cornell Vet. 1993 Apr;83(2):117-24.
The analgesic and anesthetic effects of Telazol (13.2 mg/kg, IV) and xylazine (0.11 mg/kg, IV)-Telazol (13.2 mg/kg, IV) were evaluated in 6 sheep. Anesthesia was characterized by muscle relaxation and profound analgesia with both regimens, muscle relaxation appeared to be better in sheep receiving xylazine-Telazol. The duration of analgesia was significantly longer in sheep receiving xylazine-Telazol (101.7 +/- 26 minutes) than in sheep receiving Telazol alone (41.6 +/- 15 minutes). Changes in heart rate and respiration rate were transient with both regimens. Apnea occurred in 2 sheep immediately after xylazine-Telazol administration, requiring assisted ventilation, but both sheep resumed spontaneous breathing within 2 minutes. Arterial blood pressure decreased significantly at 45 and 60 minutes after xylazine-Telazol injection. Arousal to standing was smooth, but gradual with no significant difference between the two drug regimens. In conclusion, xylazine-Telazol combination produced better muscle relaxation and longer duration of anesthesia than Telazol alone. The adverse effects induced by xylazine-Telazol were similar to that of Telazol.
在6只绵羊中评估了速眠新（13.2毫克/千克，静脉注射）以及赛拉嗪（0.11毫克/千克，静脉注射）-速眠新（13.2毫克/千克，静脉注射）的镇痛和麻醉效果。两种给药方案的麻醉特征均为肌肉松弛和深度镇痛，接受赛拉嗪-速眠新的绵羊肌肉松弛似乎更好。接受赛拉嗪-速眠新的绵羊（101.7±26分钟）的镇痛持续时间显著长于仅接受速眠新的绵羊（41.6±15分钟）。两种给药方案下心率和呼吸频率的变化都是短暂的。在给予赛拉嗪-速眠新后，2只绵羊立即出现呼吸暂停，需要辅助通气，但两只绵羊均在2分钟内恢复自主呼吸。赛拉嗪-速眠新注射后45分钟和60分钟时动脉血压显著下降。苏醒站立过程平稳，但较为缓慢，两种药物给药方案之间无显著差异。总之，赛拉嗪-速眠新联合用药比单独使用速眠新产生更好的肌肉松弛效果和更长的麻醉持续时间。赛拉嗪-速眠新引起的不良反应与速眠新相似。
