Young L E, Bartram D H, Diamond M J, Gregg A S, Jones R S
University Department of Anaesthesia, Royal Liverpool Hospital, UK.
Equine Vet J. 1993 Mar;25(2):115-9. doi: 10.1111/j.2042-3306.1993.tb02919.x.
General anaesthesia was maintained in 40 horses by the continuous intravenous infusion of a mixture of 500 ml 10% guaifenesin solution, 1 g ketamine and 500 mg xylazine. The median duration of infusion was 65 mins (interquartile range 51-95 mins). Anaesthesia was characterised by active palpebral reflexes, variable degrees of nystagmus and occasional swallowing. Swallowing was considered to be undesirable in horses undergoing laryngeal surgery, but the infusion produced satisfactory conditions for all other surgical procedures performed. Arterial blood pressure was well maintained in all cases (median mean arterial blood pressure = 85 mmHg after 30 mins anaesthesia). Heart rate and PaCO2 were significantly lower, whilst PaO2 was significantly higher in the infusion group than in a group of paired control horses which were anaesthetised with halothane. Recovery from anaesthesia was good (Grades 1-2) in 33 horses. Median times to sternal recumbency and to standing were 24 and 38 mins respectively. The infusion caused a significant fall in packed cell volume, haemoglobin concentration and red blood cell count (P < 0.01) and a significant rise in plasma glucose concentration (P < 0.01). These variables returned to pre-infusion values within 24 h.
通过持续静脉输注由500毫升10%愈创甘油醚溶液、1克氯胺酮和500毫克赛拉嗪组成的混合物，维持40匹马的全身麻醉。输注的中位持续时间为65分钟（四分位间距51 - 95分钟）。麻醉的特征为活跃的眼睑反射、不同程度的眼球震颤和偶尔的吞咽。对于接受喉部手术的马匹，吞咽被认为是不理想的，但该输注为所有其他进行的外科手术创造了满意的条件。所有病例的动脉血压均维持良好（麻醉30分钟后中位平均动脉血压 = 85 mmHg）。与一组用氟烷麻醉的配对对照马相比，输注组的心率和动脉血二氧化碳分压显著降低，而动脉血氧分压显著升高。33匹马的麻醉恢复良好（1 - 2级）。恢复至胸卧和站立的中位时间分别为24分钟和38分钟。该输注导致红细胞压积、血红蛋白浓度和红细胞计数显著下降（P < 0.01），血浆葡萄糖浓度显著升高（P < 0.01）。这些变量在24小时内恢复到输注前的值。
