Zimmermann M, Preac-Mursic V
Clinic for Maxillofacial Surgery, Munich University, Germany.
Int J Clin Pharmacol Ther Toxicol. 1993 Mar;31(3):130-6.
Bacteriological specimens from a total of 64 patients with six common, highly relevant clinical indications were collected for an in vitro investigation. By means of standard microbiological methods, 149 species of organism were differentiated, and their relative sensitivity to Taurolin, a broad spectrum chemotherapeutic and antitoxin, as well as 5 conventional finished pharmaceuticals were tested in agar diffusion tests. Taurolin, which was tested in 3 different galenic formulations, produced practically identical, but considerably wider zones of inhibition than all other compared products. In contrast to other substances which exhibited a failure rate of up to 24.8%, no gaps in the activity spectrum in the form of the lack of inhibition zone formation were observed.
收集了64例具有六种常见且高度相关临床指征的患者的细菌学标本用于体外研究。通过标准微生物学方法，鉴别出149种生物体，并在琼脂扩散试验中测试了它们对广谱化疗药和抗毒素Taurolin以及5种传统成品药物的相对敏感性。以3种不同剂型测试的Taurolin产生了几乎相同但比所有其他比较产品明显更宽的抑菌圈。与其他显示高达24.8%失败率的物质不同，未观察到以缺乏抑菌圈形成形式出现的活性谱间隙。
