de Lustig E S, Serra J A, Kohan S, Canziani G A, Famulari A L, Dominguez R O
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.
J Neurol Sci. 1993 Mar;115(1):18-25. doi: 10.1016/0022-510x(93)90062-4.
The activity of the enzyme copper-zinc superoxide dismutase (Cu-Zn SOD) has been investigated in serum and red blood cells (RBC) homogenate obtained from demented patients with associated vascular lesions (VD), demented patients with probable Alzheimer's disease (DAT) and healthy controls (CG) of the same age. The increase in SOD activity was statistically significant (P < 0.01) in RBCs homogenate of DAT and VD patients, when compared to controls, but no differences appear between the two diseases groups. Additionally, a statistically significant increase in SOD activity (P < 0.01) in DAT patients above 70 years as compared to those 50-70 years old, and a relation between SOD and age were found. No changes in SOD activity with age in healthy controls nor in vascular dementia group were detected. A statistically significant increase in Circulating SOD activity (P < 0.01) was observed in vascular patients compared to controls. The observed increase in DAT Circulating SOD activity (against CG) was not significant. The increased levels of Cu-Zn SOD, probably represent a general alteration of the oxidative processes characteristic of these dementias and suggest that the enzyme might be used as a marker.
对患有相关血管病变的痴呆患者（VD）、可能患有阿尔茨海默病的痴呆患者（DAT）以及同龄健康对照者（CG）的血清和红细胞（RBC）匀浆中的铜锌超氧化物歧化酶（Cu-Zn SOD）活性进行了研究。与对照组相比，DAT和VD患者的红细胞匀浆中SOD活性增加具有统计学意义（P < 0.01），但这两个疾病组之间未发现差异。此外，与50 - 70岁的DAT患者相比，70岁以上的DAT患者SOD活性有统计学意义的增加（P < 0.01），并且发现SOD与年龄之间存在关联。在健康对照组和血管性痴呆组中均未检测到SOD活性随年龄的变化。与对照组相比，血管性疾病患者的循环SOD活性有统计学意义的增加（P < 0.01）。观察到的DAT患者循环SOD活性增加（与CG相比）并不显著。Cu-Zn SOD水平的升高可能代表了这些痴呆症氧化过程的普遍改变，并表明该酶可用作一个标志物。
