de la Torre M R, Casado A, López-Fernández M E, Carrascosa D, Casado M C, Venarucci D, Venarucci V
Centro de Investigaciones Biológicas (CSIC), Madrid, Spain.
Neurochem Res. 1996 Aug;21(8):885-8. doi: 10.1007/BF02532336.
In order to investigate the role of two free radical detoxificant enzymes in patients with aging brain disorders, superoxide dismutase (SOD) and catalase (CAT) activities have been measured in blood from male and female human patients of different ages with several types of aging brain disorders. When compared with activities in the normal population, we have detected: 1) SOD and CAT activities are decreased in patients with Parkinson disease. 2) SOD activity seems to be normal and CAT activity is decreased in patients with dementia. 3) In the patients with stroke, SOD activity is normal, while CAT activity is decreased. SOD activity was measured in red blood cells using the Minami and Yoshikawa method. CAT activity was measured in hemolysates by the method of Aebi. We can conclude that SOD and CAT activities in patients with Parkinson disease are decreased.
为了研究两种自由基解毒酶在老年脑部疾病患者中的作用，我们检测了患有几种老年脑部疾病的不同年龄段男性和女性患者血液中的超氧化物歧化酶（SOD）和过氧化氢酶（CAT）活性。与正常人群的活性相比，我们发现：1）帕金森病患者的SOD和CAT活性降低。2）痴呆患者的SOD活性似乎正常，而CAT活性降低。3）中风患者的SOD活性正常，而CAT活性降低。采用南波和吉川法测定红细胞中的SOD活性。采用埃比法测定溶血产物中的CAT活性。我们可以得出结论，帕金森病患者的SOD和CAT活性降低。
