Perrin R, Briançon S, Jeandel C, Artur Y, Minn A, Penin F, Siest G
URA CNRS 597, Centre du Médicament, Nancy, France.
Gerontology. 1990;36(5-6):306-13. doi: 10.1159/000213215.
Cu/Zn superoxide dismutase (Cu/Zn SOD), glutathione peroxidase (GPx) and catalase, which are the three main enzymes involved in cellular protection against damage due to oxygen-derived free radicals have been assayed in plasma and erythrocytes obtained from subjects with dementia of the Alzheimer type (DAT) and from controls. Blood samples were obtained from 25 patients with DAT and from age-matched subjects without diagnoses of neurological disease (non-DAT), as well as from younger individuals (reference group). Using appropriate statistical procedures, the three enzyme activities measured in blood of the elderly were decreased if compared to the younger reference group. Moreover, a significant increase in erythrocyte Cu/Zn SOD and catalase activities of DAT patients was observed compared to the non-DAT group. These results are discussed taking the free radical theory of aging into consideration.
铜/锌超氧化物歧化酶（Cu/Zn SOD）、谷胱甘肽过氧化物酶（GPx）和过氧化氢酶是参与细胞抵御氧衍生自由基损伤的三种主要酶，已对阿尔茨海默型痴呆（DAT）患者和对照组的血浆及红细胞中的这些酶进行了检测。从25例DAT患者、年龄匹配的无神经疾病诊断的受试者（非DAT）以及较年轻个体（参考组）采集血样。采用适当的统计方法，与较年轻的参考组相比，老年人血液中测得的这三种酶活性降低。此外，与非DAT组相比，观察到DAT患者红细胞中的Cu/Zn SOD和过氧化氢酶活性显著增加。结合衰老的自由基理论对这些结果进行了讨论。
