Taniguchi S
Department of Surgical Operation Theater, Faculty of Medicine, Kyushu University, Fukuoka.
Masui. 1993 Mar;42(3):387-93.
Previously we suggested that the arterial redox potential (ARp) is one of the most reliable indicators to evaluate the severity and outcome of the acutely-ill patients. In this study we attempted to clarify which redox system, intracellular or extracellular, is mainly represented by redox potentials measured from arterial blood in the hemorrhagic shock state rabbits. The arterial pyruvate/lactate, acetoacetate/beta-hydroxybutyrate and oxidized glutathione/reduced glutathione (GSSG/GSH) ratios were measured in hemorrhagic shock rabbits, and correlations between ARp and each of these factors were analyzed. The best correlation was found between ARp and P/L ratio. This indicates that ARp well reflects the cytosolic redox state, i.e. cytosolic [NAD+]/[NADH], and also [ATP]/[ADP][Pi] theoretically. The ARp is a valuable index in evaluating the shock state and can be easily measured with Vincent's method.
此前我们曾提出，动脉氧化还原电位（ARp）是评估急重症患者病情严重程度和预后的最可靠指标之一。在本研究中，我们试图阐明在失血性休克状态的兔中，从动脉血测得的氧化还原电位主要代表细胞内还是细胞外的氧化还原系统。我们测定了失血性休克兔的动脉丙酮酸/乳酸、乙酰乙酸/β-羟丁酸以及氧化型谷胱甘肽/还原型谷胱甘肽（GSSG/GSH）比值，并分析了ARp与这些因素之间的相关性。结果发现ARp与P/L比值之间的相关性最佳。这表明ARp能很好地反映细胞溶质的氧化还原状态，即理论上的细胞溶质[NAD+]/[NADH]，以及[ATP]/[ADP][Pi]。ARp是评估休克状态的一个有价值的指标，并且可以用文森特法轻松测量。
