Odano I, Takahashi N, Nishihara M, Okubo M, Otaki H, Noguchi E, Yamazaki Y, Kimura M, Sakai K
Department of Radiology, Niigata University School of Medicine.
Kaku Igaku. 1993 Feb;30(2):189-96.
Crossed cerebellar diaschisis (CCD) is interpreted as a functional deactivation, presumably caused by a loss of excitatory or inhibitory afferent inputs on the corticopontocerebellar pathway and others. A redistribution phenomenon (RD) is usually observed in the contralateral cerebellum with CCD on delayed images of 123I-IMP SPECT. This phenomenon was analyzed in a view point of rCBF measurement in 24 patients with brain tumor, infarction and so forth. Regional CBF was measured by the microsphere method with 123I-IMP and a delayed-to-early counts ratio (D/E ratio) was used. As a result, there was no relation between rCBF and the D/E ratio in the cerebellum, which means that RD is occurred by other factors except for rCBF in the cerebellum. Regional CBF and the D/E ratio in the contralateral and ipsilateral cerebellum was 46.3 ml/100 g/min, 1.01 and 57.0 ml/100 g/min, 0.86, respectively. These results mean that the high activity of IMP gradually decreased in the ipsilateral cerebellum, while, the low activity in the contralateral cerebellum was almost stable, and the difference of both activity reduced after 5 hours and RD was observed on the delayed image. The data indicate that retention mechanism of IMP and vascular permeability are not affected in the cerebellum with CCD.
交叉性小脑失联络（CCD）被解释为一种功能失活，推测是由皮质脑桥小脑通路及其他通路上兴奋性或抑制性传入输入丧失所致。在123I-IMP SPECT延迟图像上，通常在对侧小脑观察到一种再分布现象（RD）。从rCBF测量的角度对24例脑肿瘤、脑梗死等患者的这种现象进行了分析。采用微球法结合123I-IMP测量局部脑血流量（rCBF），并使用延迟/早期计数比（D/E比）。结果显示，小脑的rCBF与D/E比之间无相关性，这意味着RD是由小脑rCBF以外的其他因素引起的。对侧和同侧小脑的局部脑血流量和D/E比分别为46.3 ml/100 g/min、1.01和57.0 ml/100 g/min、0.86。这些结果表明，同侧小脑IMP的高活性逐渐降低，而对侧小脑的低活性几乎稳定，5小时后两者活性差异减小，且在延迟图像上观察到RD。数据表明，CCD患者小脑中IMP的滞留机制和血管通透性未受影响。
