Ishino Y, Mori T, Nakata H
Department of Radiology, University of Occupational and Environmental Health, School of Medicine.
Kaku Igaku. 1993 Feb;30(2):197-201.
A rare case of Down's syndrome complicated with progressive dementia of Alzheimer type in a 41-year-old man was reported. On 123I-IMP SPECT, the patient revealed symmetrical bilateral temporo-parietal hypoperfusion. This finding seemed to support the developing dementia of Alzheimer type on the basis of clinical manifestations. 123I-IMP SPECT seemed to be useful for early diagnosis of Alzheimer-like change in a natural course of Down's syndrome.
报告了一例罕见的唐氏综合征合并阿尔茨海默型进行性痴呆的41岁男性病例。在123I-IMP单光子发射计算机断层扫描（SPECT）检查中，患者显示双侧颞顶叶对称灌注减低。基于临床表现，这一发现似乎支持了阿尔茨海默型痴呆的进展。123I-IMP SPECT似乎有助于在唐氏综合征自然病程中对阿尔茨海默样改变进行早期诊断。
