Nakayasu H, Araga S, Takahashi K, Otsuki K, Murata M
Department of Neurology, Misasa-onsen National Hospital.
Rinsho Shinkeigaku. 1991 May;31(5):557-60.
We performed 123I-IMP-SPECT to patients with Down's syndrome who were supposed to have neuropathological findings of dementia of the Alzheimer's type. In case 1, a 52-year-old man with dementia, bilateral posterior parietal low uptake and right temporal low uptake were noted. Uptake was markedly lower in the right hemisphere. Case 2, a 38-year-old man not exhibiting clinical features of dementia, presented slightly decreased uptake in bilateral posterior parietal areas. We conclude that the patterns of abnormally decreased uptake in these cases of Down's syndrome are similar to those in dementia of Alzheimer's type, and that there is a possibility to detect the predemented stage of Down's syndrome by 123I-IMP-SPECT.
我们对患有唐氏综合征且被认为具有阿尔茨海默病型痴呆神经病理学表现的患者进行了123I-异碘安非他明单光子发射计算机断层扫描（123I-IMP-SPECT）。病例1为一名52岁患有痴呆的男性，双侧顶叶后部摄取减低及右侧颞叶摄取减低被发现。右侧半球的摄取明显更低。病例2为一名38岁未表现出痴呆临床特征的男性，双侧顶叶后部区域摄取略有减低。我们得出结论，这些唐氏综合征病例中摄取异常减低的模式与阿尔茨海默病型痴呆相似，并且通过123I-IMP-SPECT有可能检测出唐氏综合征的痴呆前期阶段。
